The cleavage of lamins results in nuclear dysregulation and cell death 5 6.
What is lamin a c.
Its initial form called prelamin a undergoes a complex series of steps that are necessary for the protein to be inserted into the lamina.
Lamin a c is an intermediate filament lining the inner nuclear membrane part of the nuclear envelope.
This creates a high amount of homology between the isoforms.
Unlike lamin c lamin a is generated in a precursor form called prelamin a.
The cleavage of lamins results in nuclear dysregulation and cell death 5 6.
17 37 this is due to either the degradation of the mutated mrna carrying a premature stop codon via the non sense mediated decay pathway or to the degradation of the corresponding truncated lamin.
290 the transcript from the gene is spliced differentially to give rise to the two different forms lamin a and lamin c.
Western blot analysis showed 25 of normal lamin a levels and no truncated form was detected.
Haplo insufficiency in the cardiomyocyte nuclei.
Lamin a c belongs to the lamin family of proteins.
Lamin a c is cleaved by caspase 6 and serves as a marker for caspase 6 activation.
The lamins are components of the nuclear lamina a fibrous layer on the nucleoplasmic side of the inner nuclear membrane which is suggested to provide a framework for the nuclear envelope and may interact with chromatin.
Lamin c is a splice variant of lamin a differing only at the carboxy terminus.
Lmna also known as lamin a c is a protein that in humans is encoded by the lmna gene.
Lamins a and c are identical for the first 566 amino acids with lamin c differing only in six unique carboxy terminal amino acids.
Prelamin a and lamin c differ in structure only at the carboxyl terminus.
Lamin c does not have to undergo this processing before becoming part of the lamina.
Two isoforms lamins a and c can be created from this gene via alternative splicing.
Lamin a was detected in 10 to 20 of hgps lymphocytes.
Nuclear lamins a b1 b2 and c.
Only lamin c was present in most cells and lamin b1 was found in the nucleoplasm suggesting that it had dissociated from the nuclear envelope due to the loss of lamin a.
Lamin a c is cleaved by caspase 6 and serves as a marker for caspase 6 activation.
Lamin a c is a type v nuclear lamin.
The lamin a protein must be processed within the cell before becoming part of the lamina.
Not intended for diagnostic or therapeutic use.
Lamin a c expression explored in various explanted heart tissues from patients carrying nonsense lmna mutations revealed reduced lamin a c level i e.
For research use only.
